Research papers in the fields of Skin Biology and Dermatology

I am the author and co-author of several articles whose references are presented below.

— Berthon JY, Nachat-Kappes R, Bey M, Cadoret JP, Renimel I, Filaire E. Marine algae as attractive source to skin care. Free Radic Res. 2017 Jun;51(6):555-567.

— Pendaries V, Malaisse J, Pellerin L, Le Lamer M, Nachat R, Kezic S, Schmitt AM, Paul C, Poumay Y, Serre G, Simon M. Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte differentiation. J Invest Dermatol. 2014 Dec;134(12):2938-2946.

— Chhatriwala MK, Cipolat S, Sevilla LM, Nachat R, Watt FM. Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. J Invest Dermatol. 2012 Aug;132(8):1977-87. .

— Coudane F, Mechin MC, Huchenq A, Henry J, Nachat R, Ishigami A, Adoue V, Sebbag M, Serre G, Simon M. Deimination and expression of peptidylarginine deiminases during cutaneous wound healing in mice. Eur J Dermatol. 2011 May-Jun;21(3):376-84.

— Méchin MC, Nachat R, Coudane F, Adoue V, Arnaud J, Serre G, Simon M. [Deimination or citrullination, a post-translational modification with many physiological and pathophysiological facets]. Med Sci (Paris). 2011 Jan;27(1):49-54.

— Henry J, Hsu CY, Haftek M, Nachat R, de Koning HD, Gardinal-Galera I, Hitomi K, Balica S, Jean-Decoster C, Schmitt AM, Paul C, Serre G, Simon M. Hornerin is a component of the epidermal cornified cell envelopes. FASEB J. 2011 May;25(5):1567-76.

— Ying S, Kojima T, Kawada A, Nachat R, Serre G, Simon M, Takahara H. An intronic enhancer driven by NF-κB contributes to transcriptional regulation of peptidylarginine deiminase type I gene in human keratinocytes. J Invest Dermatol. 2010 Nov;130(11):2543-52.

— Sevilla LM, Nachat R, Groot KR, Watt FM. Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation. J Cell Sci. 2008 Nov 1;121(Pt 21):3561-9

— Nachat R, Cipolat S, Sevilla LM, Chhatriwala M, Groot KR, Watt FM. KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules. J Cell Sci. 2009 Nov 15;122(Pt 22):4035-41.

— Méchin MC, Sebbag M, Arnaud J, Nachat R, Foulquier C, Adoue V, Coudane F, Duplan H, Schmitt AM, Chavanas S, Guerrin M, Serre G, Simon M. Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases. Int J Cosmet Sci. 2007 Jun;29(3):147-68.

— Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Määttä A, Watt FM. Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol. 2007 Dec 31;179(7):1599-612.

— Foulquier C, Sebbag M, Clavel C, Chapuy-Regaud S, Al Badine R, Méchin MC, Vincent C, Nachat R, Yamada M, Takahara H, Simon M, Guerrin M, Serre G. Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation. Arthritis Rheum. 2007 Nov;56(11):3541-53.

— Raymond AA, Méchin MC, Nachat R, Toulza E, Tazi-Ahnini R, Serre G, Simon M. Nine procaspases are expressed in normal human epidermis, but only caspase-14 is fully processed. Br J Dermatol. 2007 Mar;156(3):420-7.

— Chavanas S, Méchin MC, Nachat R, Adoue V, Coudane F, Serre G, Simon M. Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis. J Dermatol Sci. 2006 Nov;44(2):63-72.

— Méchin MC, Enji M, Nachat R, Chavanas S, Charveron M, Ishida-Yamamoto A, Serre G, Takahara H, Simon M. The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations. Cell Mol Life Sci. 2005 Sep;62(17):1984-95.

— Nachat R, Méchin MC, Charveron M, Serre G, Constans J, Simon M. Peptidylarginine deiminase isoforms are differentially expressed in the anagen hair follicles and other human skin appendages.J Invest Dermatol. 2005 Jul;125(1):34-41.

— Nachat R, Méchin MC, Takahara H, Chavanas S, Charveron M, Serre G, Simon M. Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin. J Invest Dermatol. 2005 Feb;124(2):384-93.

— Chavanas S, Méchin MC, Takahara H, Kawada A, Nachat R, Serre G, Simon M. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. Gene. 2004 Apr 14;330:19-27.

— Guerrin M, Ishigami A, Méchin MC, Nachat R, Valmary S, Sebbag M, Simon M, Senshu T, Serre G. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. Biochem J. 2003 Feb 15;370(Pt 1):167-74.

Research papers in the fields of nutrition, well-being and breast cancer

— Lamas B, Nachat-Kappes R, Goncalves-Mendes N, Mishellany F, Rossary A, Vasson MP, Farges MC. Dietary fat without body weight gain increases in vivo MCF-7 human breast cancer cell growth and decreases natural killer cell cytotoxicity. Mol Carcinog. 2015 Jan;54(1):58-71.

— Nachat-Kappes R, Pinel A, Combe K, Lamas B, Farges MC, Rossary A, Goncalves-Mendes N, Caldefie-Chezet F, Vasson MP, Basu S. Effects of enriched environment on COX-2, leptin and eicosanoids in a mouse model of breast cancer. PLoS One. 2012;7(12):e51525.

— Lamas B, Goncalves-Mendes N, Nachat-Kappes R, Rossary A, Caldefie-Chezet F, Vasson MP, Farges MC. Leptin modulates dose-dependently the metabolic and cytolytic activities of NK-92 cells. J Cell Physiol. 2013 Jun;228(6):1202-9.

Basu S, Nachat-Kappes R, Caldefie-Chézet F, Vasson MP. Eicosanoids and adipokines in breast cancer: from molecular mechanisms to clinical considerations. Antioxid Redox Signal. 2013 Jan 20;18(3):323-60.